Tysabri PML attorney - Articles

Progressive Multifocal Leukoencephalopathy (PML)

Progressive multifocal leukoencephalopathy, or PML, is a potentially deadly viral infection of the brain. Although the disease is rare, it is extremely dangerous; the majority of patients die within four to five months of onset. PML usually appears only in people with significantly weakened immune system, such as people with AIDS; however, certain drugs, including the multiple sclerosis (MS) drug Tysabri, have also been shown to increase the risk of PML.

PML is classified as a progressive demyelinating disease, a disease which gradually destroys the myelin sheath surrounding nerve cells in the brain. This myelin sheath is composed of fatty cells which insulate the neuron and assist in the transmission of nerve impulses.

Symptoms of PML Demyelination

PML causes the vital myelin sheath surrounding nerve cells to slowly deteriorate in ways similar to multiple sclerosis (MS). This deterioration has serious side effects and symptoms, including:

• Loss of vision/Blurry vision
• Loss of muscle control (ataxia)
• Tingling and/or numbness
• Weakness
• Paralysis
• Seizures or coma
• Death

PML and Tysabri

Tysabri, a drug used to treat multiple sclerosis and Crohn’s disease, has been shown to increase the risk of contracting progressive multifocal leukoencephalopathy. In 2005, the drug was temporarily pulled from the market after several patients involved in clinical trials and studies developed PML. Several years later, in 2008, two new cases of Tysabri-related PML appeared, rekindling concerns about the safety of the drug.

For more information on PML and Tysabri, contact a Tysabri PML attorney at Pulaski & Middleman by dialing 800-223-3784.